Supplementing heifers with a rumen-protected dry grape extract to increase vaccination success

black and white dairy cows heifers

Oxidation and


Vaccination is an important mainstay of biosecurity and disease prevention in livestock farming. Vaccination failures represent an economic burden for the farmer. Polyphenol supplementation, is a great source of antioxidants for animals and could help reduce oxidative damage and improve the success of vaccination. For this reason, through a field trial, we evaluated the effect of a rumen-protected grape extract supplementation around vaccination on the immune response in young ruminants.

Supplementing heifers with a dry grape extract around


The trial was conducted on 22 heifers (aged from 6 to 8 months) from the same farm. These were divided into 2 group:

· BP-O group: Rumen-protected dry grape extract supplementation, Nor-Grape® BP-O

· Control group: No supplementation

Results show that the heifers from the BP-O group tended to have a greater overall antibody response to BRSV and PI-3 V. A greater total antioxidant capacity was also observed in the supplemented group.

Thus, since supplemented animals became seropositive faster and long-term immunity appeared to be improved, this supplementation strategy could be of interest to enhance the immune response during a vaccination episode by reducing oxidative stress.

working as vet
ngbpo species

Our 100% natural rumen-protected grape exctract

Nor-Grape® BP-O

Nor-Grape® BP-O is a rumen-protected grape extract standardized in polyphenols which provides soluble biological antioxidants that help compensate oxidative stress and support the animals’ immune defenses


Products from the range


Nor-Grape® 80

Compensate oxidative stress

Nor-Grape® BP-O

Compensates oxidative stress